Further investigation of pharmacologically active principles of Ipomoea pes-caprae (Linn.) Roth. (phakbungthale) / Sasithorn Wasuwat
โดย: Wasuwat, Sasithorn
ผู้แต่งร่วม: ศศิธร, วสุวัติ | Thailand Institute of Scientific and Technological Research
Language: English ชื่อชุด: Res. Proj. no. 17/8 ; Rep. no. 2ข้อมูลการพิมพ์: Bangkok : Thailand Institute of Scientific and Technological Research, 1969 รายละเอียดตัวเล่ม: 23 p.หัวเรื่อง: Ipomoea pes-caprae | Phakbungtha-leสารสนเทศออนไลน์: Click here to access full-text สาระสังเขป: More investigation is needed to identify specific end applications and any economic potential of this plant. - Author, modifiedสาระสังเขป: Preliminary screening work has indicated pharmacological activity in some extracts of I. pes-caprae. The results of further chemical and pharmacological work have shown that some fractions possess antihistaminic-like effect, and that some fractions possess the opposite property as they contract the smooth muscle of the ileum of guinea pig. Attempts to obtain a substance having antihistaminic-like effect has been made. One aqueous extract fraction has been isolated and found to contain a substance (in approximate yield of 0.05-0.07 percent) that has been identified as an ester having promising antihistaminic-like action. The antihistaminic-like effect of this active substance (referred to as IPAS) has been compared with that of three official antihistaminic drugs (antazoline hydrochloride, antazoline methanesulphonate, and diphenhydramine hydrochloride) against the action of histamine dihydrochloride 2 x 10 -6 solution on the isolated ileum of guinea pig. It has been found that about 6-9 times by weight of IPAS (6 x 10 -5 ) as compared with antazoline hydrochloride and antazoline methanesulphonate (1 x 10 -5), and about 60 times of IPAS (6 x 10 -5) as compared with diphenhydramine hydrochloride (1 x 10 -6) are required to exert similar effects.สาระสังเขป: The antagonistic effect of IPAS against jellyfish stings (using a diluted aqueous extract poison obtained from the tentacles of a large jellyfish) on the ileum of guinea pig has been examined in comparison with two official antihistamine drugs. About the same weight of IPAS (6 x 10 -5) as compared with antazoline methanesulphonate (6 x 10 -5), and about two times by weight of IPAS (6 x 10 -5) as compared with diphenhydramine hydrochloride (3 x 10 -5) are required to exert similar effects.
| ชนิดของทรัพยากร | Location | Call number | สถานะ | Last seen | Copy No. | บาร์โค้ด |
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วว. เทคโนธานี | Available | 2018-08-31 | 1 | RP1969/109 | |
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วว. เทคโนธานี | Available | 2018-08-31 | 2 | RP1969/109-2 |
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